Cdh23^sals
Chemically induced Allele Detail

Summary

• Symbol: Cdh23^sals
• Name: cadherin related 23 (otocadherin); salsa
• MGI ID: MGI:3708379
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^sals page

Progressive loss of tenting at stereociliary tips in Cdh23^sals/Cdh23^sals mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single A to T point mutation was found in exon 22 at coding nucleotide 2210. This mutation results in a Glu737Val substitution within the LDRE motif in the seventh cadherin repeat. (J:147149)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 280 strains or lines available

References

• Original: J:119820 Schwander M, et al., A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28;27(9):2163-75
• All: 5 reference(s)