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Targeted Allele Detail
Symbol: Rad51ctm1.1Sks
Name: RAD51 paralog C; targeted mutation 1.1, Shyam K Sharan
MGI ID: MGI:3707425
Synonyms: Rad51cko
Gene: Rad51c  Location: Chr11:87376645-87404954 bp, - strand  Genetic Position: Chr11, 52.08 cM
Testes abnormalities in Rad51ctm1Sks/Rad51ctm1.1Sks mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:119835
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 2 and 3 are removed by Cre-mediated recombination. The absence of protein product was confirmed by western blot analysis. (J:119835)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad51c Mutation:  20 strains or lines available
Original:  J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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