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| Caption | Histological analysis of testes. A and B: Testes from a 4 week old Rad51ctm1Sks/Rad51c+ (Rad51cneo/+, A) mouse and it's Rad51ctm1Sks/Rad51ctm1.1Sks (Rad51cko/neo, B) mutant littermate. Note the irregular shape of the seminferous tubules and the almost complete depletion of meiocytes in the mutant testis. C and D: TUNEL staining reveals elevated levels of apoptosis in the testis of a 4 week old mutant mouse (D) as compared with a heterozgyous littermate (C). Insets show higher magnifications of cross sections through TUNEL-positive seminiferous tubules. E-H: Testis from a 12 week old heterozygous male (E and G) and its infertile mutant littermate (F and H). In contrast to the control (G), very few spermatozoa (closed arrowheads) and rare spermatids (open arrowhead) were seen in testes of mutant mice. In addition, multiple layers of primary spermatocytes were also found in mutant mice (H). Arrows in G and H indicate the layers of primary spermatocytes. Interstitial tissues appeared hypertrophied in both infertile (F) and fertile mutant testes. Bars, 20um. | ||||||
| Copyright | This image is from Kuznetsov S, J Cell Biol 2007 Feb 26;176(5):581-92, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:119835 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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