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Srpxtm1Hzi
Targeted Allele Detail
Summary
Symbol: Srpxtm1Hzi
Name: sushi-repeat-containing protein; targeted mutation 1, Hirokazu Inoue
MGI ID: MGI:3706175
Synonyms: drs-
Gene: Srpx  Location: ChrX:9904216-9983879 bp, - strand  Genetic Position: ChrX, 4.62 cM, cytoband A1.2
Alliance: Srpxtm1Hzi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119999
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a floxed neomycin resistance gene in the reverse orientation that was subsequently removed via cre mediated recombination. Northern blot confirmed absence of transcript in mutant embryos. (J:119999)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Srpxtm1Hzi
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srpx Mutation:  5 strains or lines available
References
Original:  J:119999 Tambe Y, et al., Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Carcinogenesis. 2007 Apr;28(4):777-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory