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Ush2atm1Tili
Targeted Allele Detail
Nomenclature
Symbol: Ush2atm1Tili
Name: Usher syndrome 2A (autosomal recessive, mild); targeted mutation 1, Tiansen Li
MGI ID: MGI:3702040
Synonyms: Ush2a-
Gene: Ush2a  Location: Chr1:188262023-188965041 bp, + strand  Genetic Position: Chr1, 92.29 cM
Retinal degeneration in the Ush2atm1Tili/Ush2atm1Tili mouse

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118927
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Most of exon 5 was replaced by a neomycin resistance cassette. (J:118927)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ush2a Mutation:  5 strains or lines available
References
Original:  J:118927 Liu X, et al., Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4413-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory