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Targeted Allele Detail
Symbol: Spry4tm1.2Mrt
Name: sprouty RTK signaling antagonist 4; targeted mutation 1.2, Gail R Martin
MGI ID: MGI:3701941
Synonyms: Spry4deltaORF
Gene: Spry4  Location: Chr18:38586247-38601347 bp, - strand  Genetic Position: Chr18, 20.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:119280
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe entire open reading frame was deleted by flp-mediated removal of a neo cassette in the opposite orientation and a cre-mediated recombination of a floxed open reading frame. (J:119280)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry4 Mutation:  23 strains or lines available
Original:  J:119280 Klein OD, et al., Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug;11(2):181-90
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory