Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry4tm1.2Mrt mutation
(1 available);
any
Spry4 mutation
(43 available)
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craniofacial
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• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth
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growth/size/body
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• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth
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skeleton
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• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth
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skeleton
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• display ciliopathy-like limb long bone phenotypes
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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• axoneme elongation is seen in primary cilia of prenatal tibial chondrocytes
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limbs/digits/tail
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• defects in autopodium patterning
• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly
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cellular
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• axoneme elongation is seen in prenatal tibial chondrocytes
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neoplasm
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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skeleton
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• display ciliopathy-like limb phenotypes
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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limbs/digits/tail
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• defects in autopodium patterning
• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly
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neoplasm
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
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