All Phenotypes Spry4<tm1.2Mrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spry4^tm1.2Mrt
targeted mutation 1.2, Gail R Martin
MGI:3701941

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spry4^tm1.2Mrt/Spry4^tm1.2Mrt	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:3702558
cx2	Spry2^tm1.1Mrt/Spry2⁺ Spry4^tm1.2Mrt/Spry4^tm1.2Mrt	involves: 129P2/OlaHsd	MGI:6209558
cx3	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Spry4^tm1.2Mrt/Spry4⁺	involves: 129P2/OlaHsd	MGI:7309963

Allelic Composition	Spry4^tm1.2Mrt/Spry4^tm1.2Mrt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry4^tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

supernumerary teeth ( J:119280 )

• diastema teeth are seen in 16% of mice, mostly unilaterally

• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth

growth/size/body

supernumerary teeth ( J:119280 )

• diastema teeth are seen in 16% of mice, mostly unilaterally

• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth

skeleton

supernumerary teeth ( J:119280 )

• diastema teeth are seen in 16% of mice, mostly unilaterally

• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth

Allelic Composition	Spry2^tm1.1Mrt/Spry2⁺ Spry4^tm1.2Mrt/Spry4^tm1.2Mrt
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (22 available)
Spry4^tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:315670 )

• display ciliopathy-like limb long bone phenotypes

short tibia ( J:315670 )

• at E18.5

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

abnormal chondrocyte morphology ( J:315670 )

• axoneme elongation is seen in primary cilia of prenatal tibial chondrocytes

limbs/digits/tail

abnormal autopod morphology ( J:315670 )

• defects in autopodium patterning

• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly

short tibia ( J:315670 )

• at E18.5

cellular

abnormal primary cilium morphology ( J:315670 )

• axoneme elongation is seen in prenatal tibial chondrocytes

neoplasm

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ciliopathy		DOID:0060340		J:315670

Allelic Composition	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Spry4^tm1.2Mrt/Spry4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:315670 )

• display ciliopathy-like limb phenotypes

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

limbs/digits/tail

abnormal autopod morphology ( J:315670 )

• defects in autopodium patterning

• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly

neoplasm

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ciliopathy		DOID:0060340		J:315670

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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