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Targeted Allele Detail
Symbol: Smad9tm2.1Rob
Name: SMAD family member 9; targeted mutation 2.1, Elizabeth J Robertson
MGI ID: MGI:3701870
Synonyms: Smad8-, Smad8 null
Gene: Smad9  Location: Chr3:54755582-54801257 bp, + strand  Genetic Position: Chr3, 25.62 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:119296
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed Hygro cassette was inserted into intron 1 and a loxP site in intron 3. Cre-mediated recombination resulted in the excision of loxP-flanked sequences, resulting in a null allele that lacked exons 2 and 3. (J:119296)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad9 Mutation:  18 strains or lines available
Original:  J:119296 Arnold SJ, et al., Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol. 2006 Aug 1;296(1):104-18
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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