About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad9tm2.1Rob
targeted mutation 2.1, Elizabeth J Robertson
MGI:3701870
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad9tm2.1Rob/Smad9tm2.1Rob involves: 129S/SvEv MGI:3702563
cx2
 		Smad1tm1Rob/Smad1+
Smad9tm2.1Rob/Smad9tm2.1Rob 		involves: 129S/SvEv MGI:3702567
cx3
 		Smad5tm1Zuk/Smad5+
Smad9tm2.1Rob/Smad9tm2.1Rob 		involves: 129S/SvEv * 129S7/SvEvBrd MGI:3702564
cx4
 		Smad1tm1Rob/Smad1+
Smad5tm1Zuk/Smad5+
Smad9tm2.1Rob/Smad9tm2.1Rob 		involves: 129S/SvEv * 129S7/SvEvBrd MGI:3702566


Genotype
MGI:3702563
hm1
Allelic
Composition		 Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad9tm2.1Rob mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:119296 )
• homozygous mice are healthy with no apparent abnormalities




Genotype
MGI:3702567
cx2
Allelic
Composition		 Smad1tm1Rob/Smad1+
Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Rob mutation (0 available); any Smad1 mutation (32 available)
Smad9tm2.1Rob mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo

growth/size/body
abnormal embryonic growth/weight/body size ( J:119296 )

cardiovascular system

nervous system




Genotype
MGI:3702564
cx3
Allelic
Composition		 Smad5tm1Zuk/Smad5+
Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (23 available)
Smad9tm2.1Rob mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119296 )
• authors state phenotype is same as previously described for Smad5 null embryos; Smad9 deficiency does not exacerbate the Smad5 phenotype

embryo

growth/size/body
abnormal embryonic growth/weight/body size ( J:119296 )

cardiovascular system

nervous system

craniofacial

reproductive system

cellular




Genotype
MGI:3702566
cx4
Allelic
Composition		 Smad1tm1Rob/Smad1+
Smad5tm1Zuk/Smad5+
Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Rob mutation (0 available); any Smad1 mutation (32 available)
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (23 available)
Smad9tm2.1Rob mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119296 )
• no live born mice are obtained




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory