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Rag2tm1Libo
Targeted Allele Detail
Nomenclature
Symbol: Rag2tm1Libo
Name: recombination activating gene 2; targeted mutation 1, Lisa Borghesi
MGI ID: MGI:3700748
Synonyms: Erag-
Gene: Rag2  Location: Chr2:101624718-101632529 bp, + strand  Genetic Position: Chr2, 53.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84563
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.3Kb region upstream of Rag2 containing a putative enchancer (Erag) was replaced with a floxed neo cassette subsequently removed via cre mediated recombination. (J:84563)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rag2 Mutation:  47 strains or lines available
References
Original:  J:84563 Hsu LY, et al., A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity. 2003 Jul;19(1):105-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory