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Wnt1tm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Wnt1tm1Amc
Name: wingless-type MMTV integration site family, member 1; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:3700020
Synonyms: Wnt-1Enh-
Gene: Wnt1  Location: Chr15:98789857-98793837 bp, + strand  Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118582
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA 5.5 kb enhancer element, located 3' to the Wnt1 polyadenylation signal sequence, was replaced with a floxed PGKneo selection cassette by homologous recombination. This cassette was removed by cre recombination via injection of a cre-encoding plasmid into pronuclei of zygotes from heterozygous intercrosses. (J:118582)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt1 Mutation:  19 strains or lines available
References
Original:  J:118582 Danielian PS, et al., A 5.5-kb enhancer is both necessary and sufficient for regulation of Wnt-1 transcription in vivo. Dev Biol. 1997 Dec 15;192(2):300-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory