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Mapkapk5tm1Pqs
Targeted Allele Detail
Summary
Symbol: Mapkapk5tm1Pqs
Name: MAP kinase-activated protein kinase 5; targeted mutation 1, Peiqing Sun
MGI ID: MGI:3698841
Synonyms: deltaex8, Prak-
Gene: Mapkapk5  Location: Chr5:121663114-121683955 bp, - strand  Genetic Position: Chr5, 61.84 cM, cytoband F
Alliance: Mapkapk5tm1Pqs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117893
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into exon 8. Protein was not detected in mutant mice. (J:117893)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mapkapk5tm1Pqs
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapkapk5 Mutation:  30 strains or lines available
References
Original:  J:117893 Sun P, et al., PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007 Jan 26;128(2):295-308
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory