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Thbdtm2.1Emc
Targeted Allele Detail
Nomenclature
Symbol: Thbdtm2.1Emc
Name: thrombomodulin; targeted mutation 2.1, Edward M Conway
MGI ID: MGI:3698840
Synonyms: TMLeD
Gene: Thbd  Location: Chr2:148404466-148408188 bp, - strand  Genetic Position: Chr2, 73.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118000
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed neo was removed from the locus, leaving a single loxP site as well as a locus lacking the NH2-terminal domain. (J:118000)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  10 strains or lines available
References
Original:  J:118000 Conway EM, et al., The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002 Sep 2;196(5):565-77
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory