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Tg(LCAT)A31Ssf
Transgene Detail
Nomenclature
Symbol: Tg(LCAT)A31Ssf
Name: transgene insertion A31, Silvia Santamarina-Fojo
MGI ID: MGI:3696854
Synonyms: hLCAT-tg subline A31 (U line hemizygous 120 copy), line T3
Transgene: Tg(LCAT)A31Ssf  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6NCrl
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LCAT)A31Ssf expresses 1 gene
 
Mutation detailsThe transgene is a 6.2 kb human genomic DNA fragment containing the entire lecithin-cholesterol acyltransferase (LCAT) gene plus 851 bp of 5' and 1,134 bp of 3' flanking sequence. Based on Southern blot analysis, hemizygous mice of this founder line harbor 120 transgene copies. The plasma level of LCAT in mice with this transgene is 109-fold that of endogenous LCAT in non-transgenic mice. Northern blot analysis of various tissues from transgenic mice demonstrates expression of LCAT primarily in the liver, with much weaker expression in testis, brain, heart and lung. (J:118356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:118356 Vaisman BL, et al., Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J Biol Chem. 1995 May 19;270(20):12269-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory