Phenotypes associated with this allele

• Allele Symbol: Tg(LCAT)A31Ssf
• Allele Name: transgene insertion A31, Silvia Santamarina-Fojo
• Allele ID: MGI:3696854
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(LCAT)A31Ssf/Tg(LCAT)A31Ssf	C57BL/6N-Tg(LCAT)A31Ssf	MGI:5086002
tg2	Tg(LCAT)A31Ssf/0	C57BL/6N-Tg(LCAT)A31Ssf	MGI:5086001

Genotype
MGI:5086002

tg1

• Allelic Composition: Tg(LCAT)A31Ssf/Tg(LCAT)A31Ssf
• Genetic Background: C57BL/6N-Tg(LCAT)A31Ssf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:118356 )

• increase in fasting total cholesterol as well as cholesterol esters and free cholesterol

increased circulating HDL cholesterol level ( J:118356 )

increased circulating phospholipid level ( J:118356 )

abnormal circulating apolipoprotein level ( J:118356 )

• increased levels of plasma apolipoprotein A-I and A-II

abnormal circulating apolipoprotein E level ( J:118356 )

• increased levels of plasma apolipoprotein E

Genotype
MGI:5086001

tg2

• Allelic Composition: Tg(LCAT)A31Ssf/0
• Genetic Background: C57BL/6N-Tg(LCAT)A31Ssf

homeostasis/metabolism

increased circulating cholesterol level ( J:118356 )

• increase in fasting total cholesterol as well as cholesterol esters and free cholesterol

increased circulating HDL cholesterol level ( J:118356 )

increased circulating phospholipid level ( J:118356 )

• significant increase in phospholipid levels in males