Mlrrq^BALB/c
QTL Variant Detail

Summary

• QTL variant: Mlrrq^BALB/c
• Name: malaria resistance QTL; BALB/c
• MGI ID: MGI:3696567
• QTL: Mlrrq Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:41574

Malaria resistance mapped near the Mtv7 locus (96 cM) on mouse Chromosome 1 in BALB.D2-Mtv7 congenic animals. Background strain BALB/c is susceptible to infection with Plasmodium yoelii and develops severe anemia and a high degree of parasitemia whereas the congenic BALB.D2-Mtv7 is resistant (mild anemia and low degree of parasitemia). The malaria resistance locus, designated Mlrrq (malaria resistance QTL) is linked to but independent of Mtv7.

Mtv7 results in deletion of T cells bearing Vbeta6, 7, 8.1,and 9 T cell receptor elements. Neonatal BALB/c (susceptible) animals given 10⁸ BALB.D2-Mtv7 spleen cells within 24 hours after birth did not exhibit increased resistance to P. yoelli. In addition, athymic nude mice given T cells from BALB/c or BALB.D2-Mtv7 animals did not display differences in the course of infection. Therefore, the data suggests the Mtv7 locus is not involved in P. yoelli resistance, but a nearby linked gene, Mlrrq, is responsible for the effect. Spna1 at 95.4 cM is a potential candidate gene for Mlrrq.

References

• Original: J:41574 Swardson CJ, et al., Plasmodium yoelii: resistance to disease is linked to the mtv-7 locus in BALB/c mice. Exp Parasitol. 1997 Jun;86(2):102-9
• All: 1 reference(s)