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Gt(ROSA)26Sortm1Hjf
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1Hjf
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hans Jorg Fehling
MGI ID: MGI:3696099
Synonyms: R26tdRFP, Rosa26flSTOP-tdRFP, Rosa-26-rfp, ROSA26RFP, Rosa26-stop-DsRed, Rosa26:stoppfloxedtdRFP, ROSAtdRFP, ROSA-tdRFP, R-tdRFP
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1Hjf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117041
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsThis is a reporter allele for Cre activity that expresses a non-toxic tandem-dimer red fluorescent protein (2 modified DsRed subunits covalently linked) following Cre-mediated deletion of a floxed neo/stop cassette. The targeting vector inserted in intron 1 contains a neomycin/stop codon cassette and an inverted sequence coding for tandem-dimer red fluorescent protein. Inverted pairs of loxP and loxP2272 sites are arranged around these sequences in such a way that cre expression results in excision of the neo/stop codon cassette and inverts the tandem-dimer red fluorescent protein sequence permitting its expression. (J:117041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1Hjf
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  784 strains or lines available
References
Original:  J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53
All:  180 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory