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Gt(ROSA)26Sortm1Hjf
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1Hjf
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hans Jorg Fehling
MGI ID: MGI:3696099
Synonyms: R26tdRFP, Rosa26flSTOP-tdRFP, Rosa-26-rfp, ROSA26RFP, Rosa26-stop-DsRed, Rosa26:stoppfloxedtdRFP, ROSAtdRFP, ROSA-tdRFP, R-tdRFP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117041
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsThis is a reporter allele for Cre activity that expresses a non-toxic tandem-dimer red fluorescent protein (2 modified DsRed subunits covalently linked) following Cre-mediated deletion of a floxed neo/stop cassette. The targeting vector inserted in intron 1 contains a neomycin/stop codon cassette and an inverted sequence coding for tandem-dimer red fluorescent protein. Inverted pairs of loxP and loxP2272 sites are arranged around these sequences in such a way that cre expression results in excision of the neo/stop codon cassette and inverts the tandem-dimer red fluorescent protein sequence permitting its expression. (J:117041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  540 strains or lines available
References
Original:  J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53
All:  134 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory