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Snx13tm1.1Frq
Targeted Allele Detail
Nomenclature
Symbol: Snx13tm1.1Frq
Name: sorting nexin 13; targeted mutation 1, Marilyn G Farquhar
MGI ID: MGI:3696045
Synonyms: Snx13delta
Gene: Snx13  Location: Chr12:35047189-35147469 bp, + strand  Genetic Position: Chr12, 15.67 cM
Snx13tm1.1Frq/Snx13tm1.1Frq embryos are smaller, show defects in neural tube closure, vasculogenesis and placental morphology

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117102
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 3 was removed via cre-mediated recombination in ES cells, resulting in a frameshift mutation and a premature translation product containing only the N-terminal 42 residues. Absence of transcript was confirmed by RT-PCR of mutants. (J:117102)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snx13 Mutation:  19 strains or lines available
References
Original:  J:117102 Zheng B, et al., Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory