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Map4k1tm1Tht
Targeted Allele Detail
Nomenclature
Symbol: Map4k1tm1Tht
Name: mitogen-activated protein kinase kinase kinase kinase 1; targeted mutation 1, Tse-Hua Tan
MGI ID: MGI:3695423
Synonyms: HPK1-deficient, Map4k1-
Gene: Map4k1  Location: Chr7:28982050-29003279 bp, + strand  Genetic Position: Chr7, 16.94 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116613
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 were replaced with a neomycin resistance gene. Protein was not detected in immunoblot of mutant spleen or thymus. (J:116613)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map4k1 Mutation:  29 strains or lines available
References
Original:  J:116613 Shui JW, et al., Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol. 2007 Jan;8(1):84-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory