Akap8^Gt(XG068)Byg
Gene trapped Allele Detail

Summary

• Symbol: Akap8^Gt(XG068)Byg
• Name: A kinase anchor protein 8; gene trap XG068, BayGenomics
• MGI ID: MGI:3694775
• Synonyms: Akap95^GT
• Gene: Akap8 Location: Chr17:32522646-32540212 bp, - strand Genetic Position: Chr17, 17.48 cM, cytoband B2
• Alliance: Akap8^Gt(XG068)Byg page

Cleft palate in Akap8^Gt(XG068)Byg/Akap8^Gt(XG068)Byg Fign^fi/Fign^fi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XG068
• Germline Transmission: Earliest citation of germline transmission: J:116474
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing En2-betageo-pA was inserted into intron 8, resulting in the loss of the C-terminal 334 amino acids. (J:116474)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG068	CC200198 ; (MGI Seq Detail)	5' RACE	Chr17:32533086-32535218 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  30 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap8 Mutation: 44 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:116474 Yang Y, et al., Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. J Biol Chem. 2006 Aug 4;281(31):22352-9
• All: 3 reference(s)