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Akap8Gt(XG068)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Akap8Gt(XG068)Byg
Name: A kinase (PRKA) anchor protein 8; gene trap XG068, BayGenomics
MGI ID: MGI:3694775
Synonyms: Akap95GT
Gene: Akap8  Location: Chr17:32303672-32321238 bp, - strand  Genetic Position: Chr17, 17.48 cM, cytoband B2
Cleft palate in Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg Fignfi/Fignfi mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  XG068
Germline Transmission:  Earliest citation of germline transmission: J:116474
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA gene trap vector containing En2-betageo-pA was inserted into intron 8, resulting in the loss of the C-terminal 334 amino acids. (J:116474)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akap8 Mutation:  18 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:116474 Yang Y, et al., Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. J Biol Chem. 2006 Aug 4;281(31):22352-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory