Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation
(0 available);
any
Akap8 mutation
(44 available)
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normal phenotype
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• mice show no overt abnormalities
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation
(0 available);
any
Akap8 mutation
(44 available)
Fignfi mutation
(2 available);
any
Fign mutation
(39 available)
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Cleft palate in Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg Fignfi/Fignfi mice
mortality/aging
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• double mutants survive through birth, but ~50% die within a few hours of birth
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• surviving mutants are generally smaller than littermates, do not nurse well, and gradually die prior to weaning, with very few surviving to 3 weeks (3/258)
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craniofacial
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• 50% of newborns show complete cleft of the secondary palate
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respiratory system
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• some newborns display gasping
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digestive/alimentary system
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• 50% of newborns show complete cleft of the secondary palate
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homeostasis/metabolism
growth/size/body
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• 50% of newborns show complete cleft of the secondary palate
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation
(0 available);
any
Akap8 mutation
(44 available)
Fignfi mutation
(2 available);
any
Fign mutation
(39 available)
|
|
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craniofacial
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• ~20% display cleft palate
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digestive/alimentary system
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• ~20% display cleft palate
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growth/size/body
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• ~20% display cleft palate
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation
(0 available);
any
Akap8 mutation
(44 available)
Fignfi mutation
(2 available);
any
Fign mutation
(39 available)
|
|
|
craniofacial
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• 2% display cleft palate
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digestive/alimentary system
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• 2% display cleft palate
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growth/size/body
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• 2% display cleft palate
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