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Trpa1tm1Jul
Targeted Allele Detail
Nomenclature
Symbol: Trpa1tm1Jul
Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 1, David Julius
MGI ID: MGI:3692770
Synonyms: Trpa1-
Gene: Trpa1  Location: Chr1:14872648-14918862 bp, - strand  Genetic Position: Chr1, 4.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115886
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMost of exon 23, encoding the putative pore and part of the sixth transmembrane domain, was deleted. A neomycin cassette was removed through self-excision in the male germline. RT-PCR confirmed absence of transcript in mutants. (J:115886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:  65 strains or lines available
References
Original:  J:115886 Bautista DM, et al., TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24;124(6):1269-82
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory