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Targeted Allele Detail
Symbol: Rettm13.1Jmi
Name: ret proto-oncogene; targeted mutation 13.1, Jeffrey Milbrandt
MGI ID: MGI:3691588
Synonyms: RET-, Ret-EGFP
Gene: Ret  Location: Chr6:118151745-118197718 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:114682
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site and the human RET (RET9) sequence was inserted with a floxEGFPfrt-neo-frt cassette. The neo was removed by flp mediated recombination. This allele allows EGFP expression upon the cre mediated deletion of floxed cDNA from exon 1. Cre-mediated recombination removed the cDNA and allows for the expression of the reporter gene. (J:114682)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  30 strains or lines available
Original:  J:114682 Jain S, et al., RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci. 2006 Oct 25;26(43):11230-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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