All Phenotypes Ret<tm13.1Jmi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm13.1Jmi
targeted mutation 13.1, Jeffrey Milbrandt
MGI:3691588

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm13.1Jmi/Ret^tm13.1Jmi	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3692550
cn2	Ret^tm13.1Jmi/Ret^tm13Jmi Slc6a3^tm1(cre)Xz/Slc6a3⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3692551

Allelic Composition	Ret^tm13.1Jmi/Ret^tm13.1Jmi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm13.1Jmi mutation (1 available); any Ret mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:114682 )

N	• midbrain dopaminergic neurons develop normally

abnormal enteric neuron morphology ( J:114682 )

absent enteric neurons ( J:114682 )

• mice display intestinal aganglionosis

renal/urinary system

absent kidney ( J:114682 )

• renal agenesis occurs in homozygotes, identical to conventional Ret-null animals

Allelic Composition	Ret^tm13.1Jmi/Ret^tm13Jmi Slc6a3^tm1(cre)Xz/Slc6a3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm13.1Jmi mutation (1 available); any Ret mutation (52 available)
Ret^tm13Jmi mutation (1 available); any Ret mutation (52 available)
Slc6a3^tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:114682 )

• adults are modestly but significantly less active than heterozygous controls; total ambulations during a 1 hour observation session are lower in conditional null mice

• mice exhibit normal rearing behavior but travel less in the field periphery and make fewer entries into center compared to controls

nervous system

nervous system phenotype ( J:114682 )

• although Ret expression is lost, in adults the total cell counts and size of dopaminergic neurons, TH-positive fiber density in the striatum and nucleus accumbens, nigrostriatal and ventral tegmental area pathways, and levels of dopamine and its metabolites, are all similar to wild-type

• mice do not appear to have sensorimotor deficits with the modest decrease in locomotor activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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