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Dnase2atm2Osa
Targeted Allele Detail
Nomenclature
Symbol: Dnase2atm2Osa
Name: deoxyribonuclease II alpha; targeted mutation 2, Shigekazu Nagata
MGI ID: MGI:3691118
Synonyms: DNase IIflox
Gene: Dnase2a  Location: Chr8:84908624-84911461 bp, + strand  Genetic Position: Chr8, 41.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114982
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exons 3-5 were flanked with loxP sites. (J:114982)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnase2a Mutation:  87 strains or lines available
References
Original:  J:114982 Kawane K, et al., Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature. 2006 Oct 26;443(7114):998-1002
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory