Itga3^tm1Son
Targeted Allele Detail

Summary

• Symbol: Itga3^tm1Son
• Name: integrin alpha 3; targeted mutation 1, Arnaud Sonnenberg
• MGI ID: MGI:3691084
• Gene: Itga3 Location: Chr11:94935300-94967627 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Itga3^tm1Son page

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151^tm1Nki/Cd151^tm1Nki and Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114988
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked with loxP sites by inserting a loxP site and a floxed neomycin cassette into HpaI and BamH1 restriction sites, respectively. (J:114988, J:145988)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itga3^tm1Son

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga3 Mutation: 52 strains or lines available

References

• Original: J:114988 Sachs N, et al., Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006 Oct 9;175(1):33-9
• All: 13 reference(s)