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Gene trapped Allele Detail
Symbol: Epha2Gt(KST085)Byg
Name: Eph receptor A2; gene trap KST085, BayGenomics
MGI ID: MGI:3688255
Synonyms: Epha2-
Gene: Epha2  Location: Chr4:141301240-141329384 bp, + strand  Genetic Position: Chr4, 73.67 cM, cytoband D-E
Development of progressive cataract in Epha2Gt(KST085)Byg/Epha2Gt(KST085)Byg mice

Show the 3 phenotype image(s) involving this allele.

Mutant Cell Line:  KST085
Germline Transmission:  Earliest citation of germline transmission: J:112120
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1TMpfs     Vector Type: secretory trap
Mutation detailsA gene trap vector was inserted between exons 5 and 6, leading to the truncation of exons 6 to 17 encoding the second fibronectin type III repeat in the extracellular domain all the way to thecarboxyl terminal end. The remaining ectodomain encoded by exons 1 to 5 was fused to neo and betagalactosidase. (J:112120)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epha2 Mutation:  82 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:112120 Guo H, et al., Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res. 2006 Jul 15;66(14):7050-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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