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| Caption | Development of progressive cataract in Epha2Gt(KST085)Byg/Epha2Gt(KST085)Byg mice. (A) Cataracts were visible by gross inspection in homozygous mutant mice between 5 to 8 months of age, but not in heterozygous or wild-type (WT) mice. Shown are slit lamp images confirming development of cataract in mutant but not WT mice. (B) Dark field imaging of the dissected lens. Although not readily detectable by visual inspection, cataracts were found on dissected lens by 3 months of age. This lens was tilted to show denser opacity near the equator (arrow). Enucleation frequently occurred during dissection of mature cataract after 8 months (far right). (C) Retroillumination examination revealed clusters of small vacuoles by one month of age. Scale bars: 1 mm for middle panel; 150 mm for right panel. | ||||
| Copyright | This image is from Jun G, PLoS Genet 2009 Jul;5(7):e1000584, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151310 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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