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Nlrp3tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Nlrp3tm1Flv
Name: NLR family, pyrin domain containing 3; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3686871
Synonyms: Cias1-, cryopyrin, Nalp3-, Nlrp3-
Gene: Nlrp3  Location: Chr11:59541568-59566955 bp, + strand  Genetic Position: Chr11, 37.73 cM, cytoband B1.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113333
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-LacZ-MC1-neo cassette replaced exons 1 and 2. RT-PCR confirmed absence of transcript in mutant splenocytes. (J:113333)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp3 Mutation:  34 strains or lines available
References
Original:  J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
All:  139 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory