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Arhgef1tm1.1Rmt
Targeted Allele Detail
Nomenclature
Symbol: Arhgef1tm1.1Rmt
Name: Rho guanine nucleotide exchange factor (GEF) 1; targeted mutation 1.1, Raul M Torres
MGI ID: MGI:3686863
Synonyms: Lsc-
Gene: Arhgef1  Location: Chr7:24902912-24926594 bp, + strand  Genetic Position: Chr7, 13.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113295
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsApproximately 4.9 of sequence including the putative regulatory region and first exon was deleted via cre-mediated recombination. Transcript and protein were demonstrated to be absent by Northern and Western blot analyses, respectively. (J:113295)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef1 Mutation:  49 strains or lines available
References
Original:  J:113295 Rubtsov A, et al., Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov;23(5):527-38
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory