Dmpktm2Bew
Targeted Allele Detail
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Symbol: |
Dmpktm2Bew |
Name: |
dystrophia myotonica-protein kinase; targeted mutation 2, Be Wieringa |
MGI ID: |
MGI:3665271 |
Synonyms: |
DM1 (CTG)n.(CAG)n |
Gene: |
Dmpk Location: Chr7:18817774-18827746 bp, + strand Genetic Position: Chr7, 9.46 cM
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Alliance: |
Dmpktm2Bew page
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Germline Transmission: |
Earliest citation of germline transmission:
J:113264
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: Exons 13-15 were replaced with the human coding sequence for a long CTG84 repeat. Northern blot analyses demonstrated that mutant mice expressed the predicted chimeric mouse-human transcripts, resulting from alternative splicing of mouse 12 to either human exon 14 or 15.
(J:113264)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dmpk Mutation: |
37 strains or lines available
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Original: |
J:113264 van den Broek WJ, et al., Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins. Hum Mol Genet. 2002 Jan 15;11(2):191-8 |
All: |
4 reference(s) |
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