Nodal^tm1Dbc
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1Dbc
• Name: nodal growth differentiation factor; targeted mutation 1, Daniel B Constam
• MGI ID: MGI:3664773
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1Dbc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112799
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A construct consisting of a floxed PGK-hygro cassette, wild-type exons 2 and 3, a third loxP site, and a mutant exon 2 and 3 cDNA resistant to subtilisin-like proprotein convertase cleavage due to removal of the cleavage motif. Cre-mediated recombination results in production of a cleavage resistant protein. (J:112799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 41 strains or lines available

References

• Original: J:112799 Ben-Haim N, et al., The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006 Sep;11(3):313-23
• All: 1 reference(s)