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Col5a1tm1Rjw
Targeted Allele Detail
Nomenclature
Symbol: Col5a1tm1Rjw
Name: collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup
MGI ID: MGI:3664598
Synonyms: Col5a1-, ColVa1-
Gene: Col5a1  Location: Chr2:27886425-28039514 bp, + strand  Genetic Position: Chr2, 19.38 cM, cytoband A2-B
E10.5 Col5a1tm1Rjw/Col5a1tm1Rjw embryos exhibit blood pooling and absence of blood-filled vessels in yolk sacs

Show the 8 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113133
Parent Cell Line:  KG-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 3 and part of exon 4 were replaced with a neomycin resistance cassette. (J:113133)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 29 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col5a1 Mutation:  3 strains or lines available
References
Original:  J:113133 Wenstrup RJ, et al., Type V collagen controls the initiation of collagen fibril assembly. J Biol Chem. 2004 Dec 17;279(51):53331-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory