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Phenotype Images associated with this Allele
Nomenclature
Symbol: Col5a1tm1Rjw
Name: collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup
MGI ID: MGI:3664598
Synonyms: Col5a1-, Col5a1Neo, ColVa1-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
E10.5 Col5a1tm1Rjw/Col5a1tm1Rjw embryos exhibit blood pooling and absence of blood-filled vessels in yolk sacsCol5a1tm1Rjw/Col5a1tm1Rjweither: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Absence of collagen fibrils in the predermal mesenchyme of Col5a1tm1Rjw/Col5a1tm1Rjw embryosCol5a1tm1Rjw/Col5a1tm1Rjweither: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Abnormal collagen fibril architecture in Col5a1tm1Rjw/Col5a1tm1Rjw embryosCol5a1tm1Rjw/Col5a1tm1Rjweither: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Abnormal collagen fibrils in the deep dermis of 12 week old Col5a1tm1Rjw/Col5a1+ miceCol5a1tm1Rjw/Col5a1+either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
The structurally abnormal fibrils disrupt lateral fibril growth in Col5a1tm1Rjw/Col5a1+ dermisCol5a1tm1Rjw/Col5a1+involves: 129S6/SvEvTac * C57BL/6
Hyperextensible skin and decrased tensile strength of normal and wounded skin in Col5a1tm1Rjw/Col5a1+ miceCol5a1tm1Rjw/Col5a1+involves: 129S6/SvEvTac * C57BL/6
The dermis of Col5a1tm1Rjw/Col5a1+ mice contains poorly organized and less densely packed fibersCol5a1tm1Rjw/Col5a1+involves: 129S6/SvEvTac * C57BL/6
Structurally aberrant collagen fibrils in Col5a1tm1Rjw/Col5a1+ dermisCol5a1tm1Rjw/Col5a1+involves: 129S6/SvEvTac * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory