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Adam33tm1.1Chch
Targeted Allele Detail
Summary
Symbol: Adam33tm1.1Chch
Name: a disintegrin and metallopeptidase domain 33; targeted mutation 1.1, Chun Chen
MGI ID: MGI:3664558
Synonyms: ADAM33-
Gene: Adam33  Location: Chr2:130892739-130905734 bp, - strand  Genetic Position: Chr2, 63.26 cM
Alliance: Adam33tm1.1Chch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112306
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed exon 1 and neomycin resistance gene in Adam 33tm1Chch were removed via cre mediated recombination by mating with Tg(Tek-cre)1Rwng mice. Successful gene disruption was demonstrated by QRT-PCR, however LacZ expression was not detected. (J:112306)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam33 Mutation:  43 strains or lines available
References
Original:  J:112306 Chen C, et al., ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep;26(18):6950-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory