Il4^tm1(CD2)Irvr
Targeted Allele Detail

Summary

• Symbol: Il4^tm1(CD2)Irvr
• Name: interleukin 4; targeted mutation 1, Isabelle Riviere
• MGI ID: MGI:3664115
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm1(CD2)Irvr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111440
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a mutant human CD2 and a neo cassette in place of exon 1. The mutant CD2 was altered such that the cytoplasmic domain and ligand binding activity were eliminated. The endogenous gene was completely disrupted but the CD2 expression was preserved. (J:111440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 42 strains or lines available

References

• Original: J:111440 Riviere I, et al., Regulation of IL-4 expression by activation of individual alleles. Immunity. 1998 Aug;9(2):217-28
• All: 2 reference(s)