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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4tm1(CD2)Irvr
targeted mutation 1, Isabelle Riviere
MGI:3664115
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Il4tm1(CD2)Irvr/Il4+ involves: 129P2/OlaHsd * C57BL/6 MGI:3713049


Genotype
MGI:3713049
ht1
Allelic
Composition		 Il4tm1(CD2)Irvr/Il4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Irvr mutation (0 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:111440 )
N
• allele activation is initially stochastic; frequency of biallelic expression Il-4 is independent of Il-4 levels but depends on T cell receptor signaling strength

immune system
immune system phenotype ( J:111440 )
N
• human CD2 reporter gene is expressed in Th2 and Th0 cells, but not in Th1 cells expressing only IFNgamma; expression is inducible upon T cell activation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory