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Ncoa1tm1.1Hkaw
Targeted Allele Detail
Nomenclature
Symbol: Ncoa1tm1.1Hkaw
Name: nuclear receptor coactivator 1; targeted mutation 1.1, Hiroshi Kawaguchi
MGI ID: MGI:3664107
Synonyms: SRC-1-
Gene: Ncoa1  Location: Chr12:4247362-4477182 bp, - strand  Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111490
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-mediated deletion of exon 4 resulted in the creation of a stop codon at exon 5 by splicing exon 3 and 5 transcripts. The truncated protein resulting from this allele lacks the C-terminal region. (J:111490)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa1 Mutation:  148 strains or lines available
References
Original:  J:111490 Yamada T, et al., SRC-1 is necessary for skeletal responses to sex hormones in both males and females. J Bone Miner Res. 2004 Sep;19(9):1452-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory