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Vdrtm1Pcn
Targeted Allele Detail
Nomenclature
Symbol: Vdrtm1Pcn
Name: vitamin D receptor; targeted mutation 1, Pierre Chambon
MGI ID: MGI:3663379
Synonyms: VDRL2
Gene: Vdr  Location: Chr15:97854425-97910630 bp, - strand  Genetic Position: Chr15, 53.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111828
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. A floxed neomycin (neo) resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and left exon 3 floxed. (J:196471)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:  6 strains or lines available
References
Original:  J:111828 Li M, et al., Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory