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Vtcn1tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Vtcn1tm1Mak
Name: V-set domain containing T cell activation inhibitor 1; targeted mutation 1, Tak W Mak
MGI ID: MGI:3663315
Gene: Vtcn1  Location: Chr3:100825459-100896922 bp, + strand  Genetic Position: Chr3, 43.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112130
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace all of exon 3 and one third of exon 4, encoding the IgV and IgC domains, respectively, with a neomycin resistance gene. Absence of transcript was confirmed in mutant macrophages and B cells. (J:112130)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vtcn1 Mutation:  12 strains or lines available
References
Original:  J:112130 Suh WK, et al., Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 2006 Sep;26(17):6403-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory