Vtcn1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Vtcn1^tm1Mak
• Name: V-set domain containing T cell activation inhibitor 1; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3663315
• Gene: Vtcn1 Location: Chr3:100732775-100804238 bp, + strand Genetic Position: Chr3, 43.78 cM
• Alliance: Vtcn1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112130
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all of exon 3 and one third of exon 4, encoding the IgV and IgC domains, respectively, with a neomycin resistance gene. Absence of transcript was confirmed in mutant macrophages and B cells. (J:112130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vtcn1 Mutation: 22 strains or lines available

References

• Original: J:112130 Suh WK, et al., Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 2006 Sep;26(17):6403-11
• All: 3 reference(s)