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Chgatm1Gnh
Targeted Allele Detail
Nomenclature
Symbol: Chgatm1Gnh
Name: chromogranin A; targeted mutation 1, Geoffrey N Hendy
MGI ID: MGI:3653689
Synonyms: Chga-
Gene: Chga  Location: Chr12:102521228-102531287 bp, + strand  Genetic Position: Chr12, 51.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111025
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace exons 1-4 with a neomycin resistance gene. Adrenal expression of the protein was undetectable in mutants. There was no evidene of a read through transcript derived from the remaining exons. (J:111025)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Chga Mutation:  22 strains or lines available
References
Original:  J:111025 Hendy GN, et al., Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol. 2006 Aug;20(8):1935-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory