Macf1^tm1Liem
Targeted Allele Detail

Summary

• Symbol: Macf1^tm1Liem
• Name: microtubule-actin crosslinking factor 1; targeted mutation 1, Ronald K H Liem
• MGI ID: MGI:3652899
• Synonyms: Macf1^-
• Gene: Macf1 Location: Chr4:123243426-123581331 bp, - strand Genetic Position: Chr4, 57.42 cM
• Alliance: Macf1^tm1Liem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110693
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette was inserted to replace part of exons 25 and 28 and all of exons 26 and 27. The targeted sequence encoded amino acids 1053-1230, common to all isoforms. (J:110693)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macf1 Mutation: 853 strains or lines available

References

• Original: J:110693 Chen HJ, et al., The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
• All: 1 reference(s)