Phenotypes associated with this allele

• Allele Symbol: Macf1^tm1Liem
• Allele Name: targeted mutation 1, Ronald K H Liem
• Allele ID: MGI:3652899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Macf1^tm1Liem/Macf1^tm1Liem	involves: 129S6/SvEvTac * C57BL/6J	MGI:3652994

Genotype
MGI:3652994

hm1

• Allelic Composition: Macf1^tm1Liem/Macf1^tm1Liem
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:110693 )

• embryos appear to die at the gastrulation period with development halted around E7.5; embryos display a "head-without-trunk" phenotype

embryo

embryonic growth arrest ( J:110693 )

• embryonic development is arrested around E7.5

absent mesoderm ( J:110693 )

• in E7.5 embryos, mesodermal layer is absent

failure of primitive streak formation ( J:110693 )

• primitive streak is absent in early E7.5 homozygotes