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Il3ram1
Spontaneous Allele Detail
Nomenclature
Symbol: Il3ram1
Name: interleukin 3 receptor, alpha chain; mutation 1
MGI ID: MGI:3652833
Synonyms: Il3raA/J, Il3ran
Gene: Il3ra  Location: Chr14:14346001-14355493 bp, + strand  Genetic Position: Chr14, 7.08 cM
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsSequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7. (J:23971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Il3ra Mutation:  23 strains or lines available
Notes
This allele has been identified in A/J, A/WySnJ, A/HeJ, C58/J, RF/J, AKR/J, SM/J, BUB/BnJ, CE/J, and NZB/B1NJ. see J:24918.
References
Original:  J:23971 Ichihara M, et al., Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 1995 Mar 1;14(5):939-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory