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Targeted Allele Detail
Symbol: Ncoa1tm1Jkr
Name: nuclear receptor coactivator 1; targeted mutation 1, Janardan K Reddy
MGI ID: MGI:3641219
Synonyms: SRC-1-
Gene: Ncoa1  Location: Chr12:4247362-4477182 bp, - strand  Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:53063
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace most of exon B with a neomycin resistance cassette. RT-PCR confirmed absence of transcript in mutant kidney, liver and colon samples. Northern and Western blot analyses confirmed ablation of the locus. (J:53063)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa1 Mutation:  148 strains or lines available
Original:  J:53063 Qi C, et al., Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1585-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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