Dp(16Dgcr14-Sept5)3Bld
Targeted Allele Detail
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Symbol: |
Dp(16Dgcr14-Sept5)3Bld |
Name: |
duplication, Chr 16, Antonio Baldini 3 |
MGI ID: |
MGI:3640122 |
Synonyms: |
Dp(16)3, dup(16)(Es2el-Cdcrel) |
Gene: |
Dp(16Dgcr14-Sept5)3Bld Location: unknown Genetic Position: Chr16, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:67409
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Parent Cell Line: |
AB2.2 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Duplication
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Dp(16Dgcr14-Sept5)3Bld involves 37 genes/genome features (Gm26219, Gm26170, Gm15954 ...)
View all
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Mutation details: A proximal loxP site was targeted into the Es2el gene. The targeting vector replaced a 200-bp fragment containing exon 4. A second loxP site was introduced into the Sept5 gene, replacing exons 2-4. Embryonic stem cells that were double-targeted in trans were subjected to transient Cre expression and underwent recombination to produce a reciprocal duplication of the Es2el-Sept5 interval.
(J:67409)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Carrying any Dp(16Dgcr14-Sept5)3Bld Mutation: |
1 strain or line available
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Original: |
J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101 |
All: |
1 reference(s) |
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