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Malt1tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Malt1tm1Mak
Name: MALT1 paracaspase; targeted mutation 1, Tak Mak
MGI ID: MGI:3639305
Synonyms: Malt1-, Malt1tm1Jrld
Gene: Malt1  Location: Chr18:65430939-65478888 bp, + strand  Genetic Position: Chr18, 38.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109545
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 8 of the locus. Exon 8 encodes the N-terminal region of the paracaspase domain. RT-PCR confirmed loss of transcript in mutant thymocytes. Western blot failed to detect protein from mutant spleens. (J:109545)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Malt1 Mutation:  13 strains or lines available
References
Original:  J:109545 Ruland J, et al., Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity. 2003 Nov;19(5):749-58
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory