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Lig3tm1Czhu
Targeted Allele Detail
Nomenclature
Symbol: Lig3tm1Czhu
Name: ligase III, DNA, ATP-dependent; targeted mutation 1, Chengming Zhu
MGI ID: MGI:3629052
Synonyms: LIG3-
Gene: Lig3  Location: Chr11:82781109-82804274 bp, + strand  Genetic Position: Chr11, 50.23 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109063
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 8 through 13 were replaced with a neomycin resistance gene in reverse orientation. Western blot confirmed absence of protein in mutants. (J:109063)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lig3 Mutation:  27 strains or lines available
References
Original:  J:109063 Puebla-Osorio N, et al., Early embryonic lethality due to targeted inactivation of DNA ligase III. Mol Cell Biol. 2006 May;26(10):3935-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory