Phenotypes associated with this allele

• Allele Symbol: Lig3^tm1Czhu
• Allele Name: targeted mutation 1, Chengming Zhu
• Allele ID: MGI:3629052
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lig3^tm1Czhu/Lig3^tm1Czhu	involves: 129	MGI:3629224

Genotype
MGI:3629224

hm1

• Allelic Composition: Lig3^tm1Czhu/Lig3^tm1Czhu
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:109063 )

• there are reduced numbers of homozygotes found at E7.5 compared to expected

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:109063 )

• at E8.5, less than half the expected number of homozygotes are detected

embryo

embryonic growth retardation ( J:109063 )

• at E9.5 homozygous embryos resemble E8.5 wild-type

decreased embryo size ( J:109063 )

growth/size/body

embryonic growth retardation ( J:109063 )

• at E9.5 homozygous embryos resemble E8.5 wild-type

decreased embryo size ( J:109063 )

cellular

elevated level of mitotic sister chromatid exchange ( J:109063 )

• there is elevated sister chromatid exchange detected in chromosomal spreads from E8.5 Lig3-deficient embryos