Penk^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Penk^tm1Jep
• Name: preproenkephalin; targeted mutation 1, John E Pintar
• MGI ID: MGI:3628668
• Synonyms: ENK^-
• Gene: Penk Location: Chr4:4133536-4138815 bp, - strand Genetic Position: Chr4, 2.31 cM
• Alliance: Penk^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109209
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' portion of exon 3, which encodes all ENK-related peptides, was replaced with a neomycin resistance cassette. In situ hybridization failed to detect expression in mutant mice. (J:109209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Penk Mutation: 21 strains or lines available

References

• Original: J:109209 Nitsche JF, et al., Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci. 2002 Dec 15;22(24):10906-13
• All: 1 reference(s)